| School Bus Routes and Stops | Education and Early Childhood Development |
| Seat Belts | |
| Securities Complaints | Environment, Labour and Justice |
| Securities Legislation in Canada | Environment, Labour and Justice |
| Security Bonding for Private Training Schools | Innovation and Advanced Learning |
| Self Declare PST on Taxable Goods | Finance, Energy and Municipal Affairs |
| Self Employ PEI | Innovation and Advanced Learning |
| Selling Recycled Products | Environment, Labour and Justice |
| Seniors Housing Program | Community Services and Seniors |
| Seniors Property Tax Deferral Program | Finance, Energy and Municipal Affairs |
| Seniors Secretariat Grant | Community Services and Seniors |
| Seniors' Drug Cost Assistance Program | Health PEI |
| Seniors' Guide | Community Services and Seniors |
| Sensory Analysis | Innovation and Advanced Learning |
| Septic Tank Permit | Environment, Labour and Justice |
| Service Canada Centres for Youth | |
| Sewage Disposal Contractor Licence | Environment, Labour and Justice |
| Sewage Disposal Permit | Environment, Labour and Justice |
| Sewage Disposal System Pumpers License | |
| Sexual Deviance Assessment/ Treatment Program | Environment, Labour and Justice |
| Sexually Transmitted Disease Program | Health PEI |
| Sheriff | Environment, Labour and Justice |
| Sherwood Home | Health PEI |
| Signage Regulation | Tourism and Culture |
| Signage Review | Tourism and Culture |
| Site Planning | Environment, Labour and Justice |
| Site Suitability Assessment | Environment, Labour and Justice |
| Skunks | Agriculture and Forestry |
| Small Business | Finance PEI |
| Small Claims - Supreme Court | |
| Small Seeds Inspection | |
| Snow Removal | Transportation and Infrastructure Renewal |
| Social Assistance Program | Community Services and Seniors |
| Social Insurance Number | |
| Soil, Feed and Water Chemistry Testing Laboratory | Agriculture and Forestry |
| Souris Hospital | Health PEI |
| Special Event Signage | Tourism and Culture |
| Special Needs Grant for Licensed Early Childhood Centres | Education and Early Childhood Development |
| Special Projects Program | |
| Special Waste Disposal Permit | Environment, Labour and Justice |
| Speech Language Pathology | Health PEI |
| St. Eleanor's House | Health PEI |
| Statutes | Environment, Labour and Justice |
| Stay-A-While Day Program | Health PEI |
| Stewart Memorial Hospital | Health PEI |
| Strawberry Certification Program | |
| Stray Dogs | |
| Street and Road Maintenance - Provincial | Transportation and Infrastructure Renewal |
| Studded Tires | |
| Student Contract for Private Training Schools | Innovation and Advanced Learning |
| Student Grants and Loans Programs | Innovation and Advanced Learning |
| Subdividing Land | Environment, Labour and Justice |
| Summer Student Vacation Planner | Tourism and Culture |
| Summerset Manor | Health PEI |
| Summerside Animal Control By-Law | |
| Supplementary Return for Motor Vehicle Dealers | Finance, Energy and Municipal Affairs |
| Supreme Court of PEI | |
| Suspended License Appeals | Transportation and Infrastructure Renewal |
| Swimming Pool Inspection | |
| Swimming Pools and Waterslides | |